The in vivo assessment of nimesulide cyclooxygenase-2 selectivity
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چکیده
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The discovery of a second isoform of cyclooxygenase (COX) led to the search for compounds that could selectively inhibit COX-2 in humans while sparing prostaglandin formation from COX-1. Celecoxib and rofecoxib were among the molecules developed from these efforts. We report here the pharmacological properties of a third selective COX-2 inhibitor, valdecoxib, which is the most potent and in vit...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 1999
ISSN: 1460-2172
DOI: 10.1093/rheumatology/38.suppl_1.19